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Sermorelin (GRF 1–29 NH₂) 10mg, a synthetic GHRH receptor agonist reference peptide for in-vitro somatotropic axis and GH signaling research. Lab use only.
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3-4 units
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5-9 units
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10+ units
12% off
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For Research Use Only. Not intended for human consumption, veterinary use, or any clinical application, sold exclusively for laboratory and in-vitro research. By purchasing, you confirm you are a qualified researcher.
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Category
Peptides
Purity
High purity (research grade)
Storage
Refrigerate at 2–8°C
Form
Lyophilized powder
Shipping
Ships in 24–48 business hours · discreet
Overview
About Sermorelin 10mg
Sermorelin (GRF 1–29 NH₂) is a synthetic 29-amino-acid peptide corresponding to the biologically active N-terminal fragment of endogenous human growth hormone-releasing hormone (GHRH). This truncated sequence retains the full intrinsic activity of native GHRH, making sermorelin a widely used reference compound for probing GHRH receptor pharmacology in the laboratory.
As a GHRH receptor agonist, sermorelin engages somatotroph cells to model the physiological, pulsatile secretion of growth hormone from the anterior pituitary. Because it drives the endogenous secretory axis rather than substituting for growth hormone itself, researchers employ it in cell-culture and preclinical models to study feedback regulation, receptor signaling dynamics, and the neuroendocrine control of the somatotropic axis.
Key research areas
GHRH receptor signaling: characterizing agonist binding, cAMP responses, and receptor desensitization in somatotroph and transfected cell models.
Pulsatile GH release: investigating the amplitude and frequency of growth hormone secretion patterns in in-vitro pituitary preparations.
IGF-1 axis studies: examining downstream somatotropic signaling and feedback regulation in preclinical research systems.
Neuroendocrine aging: modeling age-related changes in somatotropic axis function and secretory dynamics.
Sleep and body composition models: exploring associations between GH secretion, sleep architecture, and metabolic parameters in research contexts.
Storage: store lyophilized material at -20°C, protected from light; reconstituted solutions should be kept refrigerated and used promptly
Quality: third-party tested for identity and purity; a Certificate of Analysis is available on request
Echo Peptides supplies this material sourced from qualified production channels for in-vitro laboratory and research use only. Not for human or veterinary use, and not intended for diagnostic or therapeutic applications.
Regulatory notice. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease, and not for human or veterinary use. Sold exclusively for laboratory and in-vitro research by qualified professionals — always follow proper laboratory safety protocols.
This vial
Working with the 10mg vial
This vial contains 10 mg of lyophilized material. Reconstitution does not change that mass — it changes the volume it occupies — so the concentration you end up with is set entirely by how much diluent you add.
Diluent added
Concentration
Concentration
Molarity
1 mL
10 mg/mL
10000 µg/mL
2.98 mM
2 mL
5 mg/mL
5000 µg/mL
1.49 mM
3 mL
3.33 mg/mL
3333 µg/mL
0.993 mM
5 mL
2 mg/mL
2000 µg/mL
0.596 mM
Molarity uses this compound's verified molecular weight of 3357.9 g/mol.
Figures are unit conversions for handling reference material in vitro. Nothing here is a dose or a protocol.
Frequently Asked Questions
What is the difference between sermorelin and full-length GHRH?
Sermorelin corresponds to only the first 29 amino acids (GRF 1–29 NH₂) of the 44-residue native growth hormone-releasing hormone. This N-terminal fragment carries the full receptor-activating potency of the parent molecule, so researchers use it as a compact, well-characterized GHRH receptor agonist in laboratory models.
Why is sermorelin studied as a reference compound for the somatotropic axis?
Because it acts upstream at the GHRH receptor to stimulate the pituitary's own pulsatile growth hormone output rather than replacing growth hormone directly, sermorelin lets researchers examine intact feedback regulation, receptor signaling, and IGF-1 dynamics in cell-culture and preclinical systems.
How should this sermorelin preparation be reconstituted and stored for research?
The 10 mg lyophilized powder is typically dissolved in sterile bacteriostatic or distilled water in the laboratory. Store the unreconstituted vial at -20°C away from light; keep reconstituted solutions refrigerated and use them promptly to preserve peptide integrity across experiments.
