GHK-Cu is a naturally occurring copper-binding tripeptide in which the sequence glycyl-L-histidyl-L-lysine (Gly-His-Lys) chelates a copper(II) ion to form a stable complex. First identified in human plasma, this small molecule has become a widely referenced compound in matrix biology because of the way its histidine and terminal amine residues coordinate copper, positioning the metal for participation in redox-sensitive processes.

In laboratory settings, researchers use GHK-Cu as a reference compound to probe how copper delivery influences fibroblast behavior, extracellular matrix turnover, and antioxidant signaling in cell-culture and other in-vitro systems. Its defined sequence and characteristic blue coloration—arising from the copper coordination—make it a convenient model for studying peptide-metal interactions and downstream gene-expression readouts under controlled conditions.

Key research areas

  • Collagen and extracellular matrix remodeling — evaluating fibroblast synthesis of structural proteins in cultured tissue models
  • Antioxidant and anti-inflammatory pathways — examining copper-dependent redox signaling in vitro
  • Wound-healing and tissue-regeneration models — preclinical bench studies of cellular migration and repair
  • Gene-expression modulation — profiling transcriptional responses to peptide-copper exposure in cellular assays
  • Peptide-metal coordination chemistry — investigating copper(II) binding and complex stability

Specifications

  • Amount: 50mg
  • Form: Lyophilized blue powder
  • Sequence: Gly-His-Lys · Cu²⁺
  • Molecular weight: ~404 Da (complex)
  • Solubility: Soluble in water or bacteriostatic water
  • Storage: Refrigerate at 2–8°C
  • Quality: Third-party tested for identity and purity; a Certificate of Analysis is available

Echo Peptides sources GHK-Cu 50mg from qualified production channels for laboratory and in-vitro research use only. It is not intended for human or veterinary use, nor for any diagnostic or therapeutic application.